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pentobarbital will lessen the extent or impact of buprenorphine, long-acting injection by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Sufferers who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers need to be monitored to make certain b